Ịghọta Narrowband UVB Phototherapy

Ọgwụgwọ nhọrọ maka psoriasis, vitiligo, na eczema

Narrowband UVB Phototherapy – Ihe ndabere

"Narrowband" UVB aghọwo phototherapy t n'ihi na ọ na-anapụta ọnụ ọgụgụ kasị ukwuu nke kacha uru wavelengths nke ìhè UV, na-ebelata ndị nwere ike emerụ wavelengths. 

ot "Brọdband" Ọkụ UVB na-ebunye ọkụ n'ọtụtụ dị iche iche n'ofe UVB dị iche iche, gụnyere ma ogologo ogologo ọgwụgwọ kpọmkwem maka ọgwụgwọ ọrịa anụ ahụ, gbakwunyere ogologo ogologo ogologo nke na-akpata ọkụ ọkụ (erythema). Sunburning nwere uru ọgwụgwọ na-adịghị mma, na-abawanye ohere nke ọrịa cancer anụ ahụ, na-akpata ahụ erughị ala nke onye ọrịa, na-amachikwa ọnụọgụ ọgwụgwọ UVB nwere ike iwere.  

"Akụkụ dị warara" N'aka nke ọzọ, oriọna UVB na-ebunye ọkụ n'ofe ogologo ogologo ogologo nke gbadoro anya na usoro ọgwụgwọ yana ntakịrị na nso ọkụ anwụ, na-erigbu "ebe dị ụtọ" n'etiti abụọ ahụ gburugburu 311 nm. Ya mere, UVB-Narrowband dị nchebe ma dị irè karịa UVB-Broadband, mana ọ chọrọ ma ogologo oge ọgwụgwọ ma ọ bụ akụrụngwa nwere ọtụtụ bulbs iji nweta oke dose, nke bụ na mmalite nke obere akpụkpọ anụ ahụ na-acha ọbara ọbara mgbe ọgwụgwọ gasịrị, nke a maara dị ka "sub-erythema" . Ụdị UVB-Narrowband nke Solarc nwere mgbakwunye “UVB-NB” na nọmba nlereanya, dị ka 1780UVB-NB. Ụdị UVB-Broadband nke Solarc nwere sọsọ “UVB” dị ka 1740UVB. Philips Lighting nke Holland mepụtara “Narrowband UVB” ma marakwa ya dị ka: Narrow Band UVB, UVB Narrowband, UVB‑NB, NB‑UVB, TL/01, TL‑01, TL01, 311 nm, wdg, (ebee. "01" bụ koodu Philips phosphor agbakwunyere na nọmba akụkụ bọlbụ UVB-Narrowband).

Na maka nkọwa zuru ezu: 

Ịghọta Narrowband UVB Phototherapy

"Narrowband" UVB (UVB-NB) aghọwo ọgwụgwọ phototherapy nke nhọrọ maka psoriasis, vitiligo, atopic dermatitis (eczema), na nsogbu akpụkpọ anụ ndị ọzọ na-anabata. Ịghọta uru nke "Narrowband" UVB megide "Broadband" UVB phototherapy chọrọ nghọta nke ọkụ na usoro ọ na-emetụta.

Ihe dị iche iche nke radieshon anya (ìhè) bụ nke dị iche iche wavelengths nke "ìhè" sitere na 100 nanometers (nm) na ultraviolet (UV) nso na 1 millimeter (mm) na infrared (IR). Ìhè a na-ahụ anya na-esi n'ihe dị ka 380 nm (violet) ruo 780 nm (ọbara ọbara) ma mara ya dị ka "agba" nke anyị na-eji anya anyị na-ahụ. Ultraviolet bụ ihe a na-adịghị ahụ anya yana sitere na 380 nm gbadaa 100 nm, wee kewaa ya na UVA (315-380 nm), UVB (280-315 nm), na UVC (100-280 nm).

ISI A na-egosi otú “ìhè” sitere n'okike na-eru n'elu ụwa mgbe a kpochachara ya site na ikuku nke ụwa. Ụmụ mmadụ etolitela ịbụ ndị a na-ekpughere n'ogologo ogologo oge niile a, yabụ akpụkpọ ahụ anyị emepụtala nzaghachi iji ìhè mee ihe bara uru (Vitamin D) na iji chebe anyị pụọ na ikpughe (ihe nketa akpụkpọ anụ na tanning). A na-eme ka "UVB Narrowband" pụta ìhè na 311 nm ma na-apụta n'ụzọ nkịtị na ìhè anyanwụ, ma ọ bụghị na nnukwu ego. Ikuku ụwa na-ekpochapụ ihe fọrọ nke nta ka ọ bụrụ ìhè niile na-erughị ihe dịka 300 nm.
nghọta narrowband uvb phototherapy
narrawband uvb phototherapy

Ogologo ebili mmiri dị iche iche nke "ìhè" na-emepụta mmetụta dị iche iche na ihe. A mụọla ọtụtụ usoro dị mkpa na nkà mmụta sayensị iji chọpụta ntinye aka nke ogologo ogologo ọ bụla na usoro ọmụmụ. A na-eji eserese ndị a maara dị ka “ụdị ụdịdị omume” iji kọwaa mmekọrịta ndị a. Ka “mmetụta ụdị omume dị iche iche” na-abawanye, ka usoro ahụ na-anabatakwu n'ogologo nfe ahụ.

A mụọla ụdịdị dị iche iche maka psoriasis1,2 iji chọpụta na ogologo oge ọgwụgwọ ọgwụgwọ bụ 296 ruo 313 nm. Dị ka e gosiri na ISIOKWU B, oriọna UVB-Broadband a na-ahụkarị na-ekpuchi oke a ma ejiri ya mee ihe nke ọma karịa afọ 60.

A mụọla ụdịdị dị iche iche maka “ọkụ anwụ” nke akpụkpọ ahụ mmadụ, nke a makwaara dị ka “erythema”.11 Erythema na-achịkwa ebili mmiri dị ala (ihe na-erughị 300 nm) nke oke UVB. N'ụzọ dị mwute, oriọna UVB-Broadband na-emekarị na-emepụta "ìhè" dị ukwuu n'ụdị erythemogenic a. Ogologo ebili mmiri ndị a na-emepụta ọkụ ma nwee uru ọgwụgwọ dị ntakịrị. Kedu ihe ọzọ, mmalite nke ọkụ na-egbochi dose UVB3 na erythema bụ ihe ize ndụ maka ọrịa kansa anụ ahụ. Erythema na-ebutekwa ahụ erughị ala nke onye ọrịa, nke nwere ike ịkụda ụfọdụ ndị ọrịa ịra ọgwụgwọ. Ebe ndo isi awọ dị na Nọmba C na-enye ihe ngosi eserese nke nnukwu ọdịnaya erythemogenic nke UVB-Broadband.

uvbbroadband erythema nghọta warara eriri uvb phototherapy

"Ya mere gịnị kpatara na ị gaghị emepụta ihe ọkụ ọkụ nke na-emepụta ọtụtụ n'ime mmepụta ya na psoriasis action spectrum ma na-ebelata ìhè na erythema action spectrum?"

uvbnarrowband erythema nghọta warara eriri uvb phototherapy

N'ọgwụgwụ 1980, Philips Lighting nke Holland mepụtara ụdị oriọna dị otú ahụ, nke a maara dị ka oriọna "TL-01" ma ọ bụ "UVB Narrowband". Obere ebe ndo isi awọ dị na Nọmba D na-egosi na oriọna UVB-Narrowband nwere nnukwu mmepụta erythemogenic dị obere (ike anwụ anwụ) karịa oriọna UVB-Broadband. Nke a pụtara na enwere ike ibunye UVB ọgwụgwọ karịa tupu erythema emee, ebe ọ bụ na erythema bụ ihe dị ize ndụ maka ọrịa kansa anụ ahụ, oriọna ọhụrụ ndị a kwesịrị ịbụ obere carcinogenic maka otu nsonaazụ ọgwụgwọ ahụ.4,5,6,7. Ọzọkwa, ma dị oke mkpa maka ihe ịga nke ọma nke ụlọ UVB-Narrowband phototherapy hụrụ, ọ ga-ekwe omume na a na-achịkwa ọrịa ahụ n'ebughị ụzọ rute ọnụ ụzọ erythemogenic.9,10, nke bụ nsogbu mgbe niile na ọgwụgwọ UVB-Broadband. Ọ bụ ihe na-adọrọ mmasị ịmara na ọnụ ọgụgụ kasị elu nke UVB-Narrowband curve dị ihe dị ka okpukpu iri karịa UVB-Broadband curve, ya mere isi mmalite nke aha "Narrowband".

Nnyocha ndị ọzọ na-adịbeghị anya ekwenyela na nchoputa ndị a ma kpebiekwa na UVB-Narrowband nwere obere ọkụ ọkụ na ogologo oge mgbapụta karịa UVB-Broadband. Mgbe atụnyere PUVA (Psoralen + UVA-1 ìhè), UVB-Narrowband nwere mmetụta dị ntakịrị ntakịrị ma dochie ya n'ọtụtụ ọnọdụ.8.

Otu mwepu nke UVB-Narrowband bụ na, n'ihi na oke usoro onunu ogwu na-ejedebere site na mmalite nke obere erythema, na UVB-Narrowband bụ obere erythemogenic karịa UVB-Broadband, a chọrọ oge ọgwụgwọ ogologo oge. Enwere ike ịkwụ ụgwọ nke a site n'ịba ụba nke bulbs na ngwaọrụ ahụ4,5,6,7. Dịka ọmụmaatụ, dabere na phototherapy ụlọ nke Solarc mgbe nleba anya ahịa maka UVB-Broadband, 4-bulb 1740UVB na-enye oge ọgwụgwọ ezi uche dị na ya; ebe maka UVB-Narrowband, 8-bulb 1780UVB-NB bụ nhọrọ a na-ahụkarị. Usoro echiche nke ikike erythemogenic nke UVB-Broadband na UVB-Narrowband dị na nso nke 4:1 ruo 5:1.

Ọrịa ndị ọzọ dị ka vitiligo, eczema, mycosis fungoides (CTCL), na ọtụtụ ndị ọzọ ka ejirila UVB-Narrowband gwọọ ya nke ọma, n'ozuzu maka otu ihe ahụ dị ka akọwara n'elu maka psoriasis.

Uru ọzọ na-adọrọ mmasị nke UVB-Narrowband bụ na ọ nwere ike ịbụ ụdị oriọna fluorescent kacha mma maka ịmepụta vitamin D (Nọmba E) na akpụkpọ ahụ mmadụ, maka ojiji kama ìhè anyanwụ nkịtị (nke gụnyere UVA na-emerụ ahụ), ma ọ bụ maka ndị na-enweghị ike ịmịnye vitamin D (mbadamba) zuru oke n'ihi nsogbu dị na eriri afọ. Isi okwu nke vitamin D enwetawo nlebara anya mgbasa ozi dị egwu n'oge na-adịbeghị anya, na maka ezi ihe kpatara ya. Vitamin D dị oké mkpa maka ahụ ike mmadụ, ma ọtụtụ ndị mmadụ enweghị ụkọ, karịsịa ndị bi n'ebe dị elu, dị anya site na equator ụwa. A na-enwewanye ihe akaebe na vitamin D na-echebe megide mmepe nke ọtụtụ ọrịa na-adịghị ala ala, gụnyere ọrịa cancer (ara, colorectal, prostate), ọrịa obi, multiple sclerosis, osteomalacia, osteoporosis, ụdị 1 ọrịa shuga mellitus, rheumatoid ogbu na nkwonkwo, ọbara mgbali elu, na ịda mbà n'obi. Maka ozi ndị ọzọ, biko gaa na webụsaịtị ndị a: Vitamin D Phototherapy FAQ & oriọna maka vitamin D.

uvbnarrowband vitamin nghọta narrowband uvb phototherapy

Echiche a na-enwekarị na mpaghara dermatology bụ na UVB-Narrowband ga-emecha dochie UVB-Broadband dị ka nhọrọ ọgwụgwọ, karịsịa maka phototherapy ụlọ. Nke a na-akwado nke ọma site n'usoro Solarc Systems 'usoro na ire akụrụngwa phototherapy ụlọ, na ire nke ngwaọrụ UVB-NB ugbu a karịa ahịa UVB-BB n'ihe dịka 100:1. Ụdị UVB-Narrowband nke Solarc nwere mgbakwunye "UVB‑NB" na nọmba nlereanya, dịka 1780UVB-NB. Ụdị UVB-Broadband nke Solarc nwere sọsọ “UVB” dị ka 1740UVB.

Solarc Systems ga-amasị ikele ndị ezigbo mmadụ na Philips Lighting maka ịmepụta ahịrị ngwaahịa UVB-Narrowband, yana inyere ọtụtụ n'ime anyị aka gburugburu ụwa ijikwa nsogbu akpụkpọ ahụ anyị n'enweghị nsogbu na nke ọma. Cheta na: Onu ogugu ejiri mee ihe n'ime akwukwo a bu ihe nnochi anya di mfe. Usoro UVB-Broadband sitere na Solarc/SolRx 1740UVB yana usoro UVB-Narrowband sitere na Solarc/SolRx 1760UVB‑NB.

Anyị na-agba gị ume ka ị nyochaa isiokwu a dị mkpa n'ihu.

References:

1 PARRISH JA, JAENICKE KF (1981) Action Spectrum maka phototherapy nke psoriasis. J itinye ego Dermatol. 76 359
2 FISCHER T, ALSINS J, BERNE B (1984) Ultraviolet-action spectrum na nyocha nke oriọna ultraviolet maka ọgwụgwọ psoriasis. Int. J. Dermatol. 23 633
3 BOER I, SCHOTHORST AA, SUURMOND D (1980) UVB phototherapy nke psoriasis. Dermatologica 161 250
4 VAN WEELDEN H, BAART DE LA FAILLE H, Young E, VAN DER LEUN JC, (1988) Mmepe ọhụrụ na UVB phototherapy nke psoriasis. Akwụkwọ akụkọ Britain nke Dermatology 119
5 KARVONEN J, KOKKONEN E, RUOTSALAINEN E (1989) oriọna UVB 311nm na ọgwụgwọ psoriasis na usoro Ingram. Acta Derm Venereol (Stockh) 69
6 JOHNSON B, GREEN C, LAKSHMIPATHI T, FERGUSON J (1988) Ultraviolet radiation phototherapy maka psoriasis. Ojiji nke ọhụrụ warara gbalaga UVB fluorescent oriọna. Proc. 2nd Euro. Photobiol. Congr., Padua, Italy
7 GREEN C, FERGUSON J, LAKSHMIPATHI T, JOHNSON B 311 UV phototherapy - ọgwụgwọ dị irè maka psoriasis. Ngalaba Dermatology, Mahadum Dundee
8 TANEW A, RADAKOVIC-FIJAN S, SC
HEMPER M, HONIGSMANN H (1999) Narrowband UV-B phototherapy vs photochemotherapy na ọgwụgwọ nke plaque ụdị psoriasis. Arch Dermatol 1999;135:519-524
9 WALTERS I, (1999) Suberythematogenic narrow-band UVB dị irè karịa UVB omenala na ọgwụgwọ psoriasis vulgaris. J Am Acad Dermatol 1999;40:893-900
10 HAYKAL KA, DESGROSEILLIERS JP (2006) Nkeji ụlọ Ultraviolet B dị warara ọ bụ nhọrọ bara uru maka ọgwụgwọ na-aga n'ihu ma ọ bụ na-ahụ maka ọrịa nke na-anabata foto? Akwụkwọ nke Medicine Cutaneous & Surgery, Mpịakọta 10, Isi 5 : 234-240
11 Erythema ntụaka omume ụdịdị dị iche iche na ọkọlọtọ erythema dose ISO-17166: 1999 (E) | CIE S 007/E-1998
12 Action Spectrum maka mmepụta nke Previtamin D3 na akpụkpọ mmadụ CIE 174: 2006